Argireline

SKU: orb1296692

Description

Argireline (Acetyl hexapeptide-3) is a synthetic peptide that reduces acetylcholine release by inhibiting SNARE complex formation. It is widely used in dermatological research for studying mechanisms of wrinkle formation and has demonstrated anti-aging effects in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 616204-22-9
• MW: 888.99
• Purity: 99.65%
• Formula: C₃₄H₆₀N₁₄O₁₂S
• SMILES: [C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCCNC(=N)N)=O)(NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(C)=O)=O)CCC(O)=O)=O)CCSC)=O)CCC(N)=O
• Target: Calcium Channel,Others
• Solubility: DMSO:10 mM

Bioactivity

• In Vivo:
  Argireline was administered topically to elderly mice twice daily for six weeks, resulting in notable histological improvements in skin tissue. Specifically, the quantity of type I collagen fibers increased significantly (P < 0.01), and the amount of type III collagen fibers decreased (P < 0.05). This demonstrates Argireline's capability to enhance the histological architecture of skin tissue and restore aged skin.
• In Vitro:
  The incubation of Argireline solution in varying concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM) for 48 hours exhibits a dose-dependent antiproliferative effect. The solution also shows similar effects on HSF cells. Argireline in low concentrations does not affect cell proliferation .

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acetyl hexapeptide 3, Acetyl hexapeptide3, Acetyl hexapeptide-3, Argireline, Antiwrinkle, anti-aging, BoNTs, neurotransmitter, non-toxic, inhibit, Inhibitor, skin-permeable, short-chain, peptide

Compound Identifiers

PubChem CID

11228338