ARCC-4

SKU: orb1989542

Description

ARCC-4 is a potent VHL-recruiting PROTAC that induces low-nanomolar degradation of the androgen receptor (DC50 = 5 nM). It outperforms enzalutamide and effectively targets clinically relevant AR mutants, making it a valuable tool for prostate cancer research in both cellular and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1973403-00-7
• MW: 1024.18
• Formula: C₅₃H₅₆F₃N₇O₇S₂
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(cc2)-c2ccc(cc2)N2C(=S)N(C(=O)C2(C)C)c2ccc(C#N)c(c2)C(F)(F)F)C(C)(C)C)cc1
• Target: Androgen Receptor,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

122428515