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AR antagonist 15

SKU: orb3135385

Description

AR antagonist 15 is an orally active androgen receptor (AR) antagonist with an IC50 of 97 nM for ART787A. It impairs AR nuclear translocation, hinders AR homodimerization, and inhibits AR-regulated gene transcription by competitively binding to the ligand-binding pocket. AR antagonist 15 significantly reduces prostate-specific antigen (PSA) levels and induces apoptosis by decreasing the expression of apoptosis-related proteins. This compound is useful for prostate cancer research.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1790308-86-9
MW346.44
FormulaC18H22N2O3S
SMILESO=S(=O)(NC1=CC=C(OCC=2C=CC=CC2)C=C1)N3CCCCC3
TargetAndrogen Receptor,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information