Enzalutamide carboxylic acid

SKU: orb1299114

Description

Enzalutamide carboxylic acid is a potent androgen receptor (AR) antagonist used in research. It is applied in both in vitro binding assays and in vivo xenograft studies to investigate prostate cancer mechanisms and therapeutic resistance.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1242137-15-0
• MW: 451.39
• Purity: 99.17% (May vary between batches)
• Formula: C₂₀H₁₃F₄N₃O₃S
• SMILES: CC1(C)N(C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F)c1ccc(C(O)=O)c(F)c1
• Target: Androgen Receptor,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.43 mM);DMSO:25 mg/mL (55.38 mM)

Bioactivity

• In Vivo:
  Enzalutamide is an oral agent for the treatment of metastatic castration-resistant prostate cancer (mCRPC); N-desmethyl enzalutamide is its active metabolite, which has clinically relevant anti-androgen capacities similar to enzalutamide, and carboxylic acid enzalutamide is an inactive metabolite.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

castration-resistant, DrugMetabolite, Drug Metabolite, cancer, AndrogenReceptor, Androgen Receptor, androgen, metabolite, metastatic, inhibit, MDV3100 carboxylic acid, Inhibitor, Enzalutamide carboxylic acid, receptor, prostate

Compound Identifiers

PubChem CID

46898522