Apramycin sulfate

SKU: orb1309823

Description

Apramycin sulfate, also known as Nebramycin II, is an aminoglycoside antibiotic used in research. It is applied in both in vitro and in vivo studies to investigate bacterial protein synthesis inhibition and mechanisms of antibiotic action, particularly against Gram-negative pathogens.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 65710-07-8
• MW: 637.66
• Purity: 99.96% (May vary between batches)
• Formula: C₂₁H₄₃N₅O₁₅S
• SMILES: OS(O)(=O)=O.[H][C@]12C[C@@H](N)[C@@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)O[C@]1([H])[C@H](O)[C@H](NC)[C@@H](O[C@H]1O[C@H](CO)[C@@H](N)[C@H](O)[C@H]1O)O2
• Target: Antibiotic,Antibacterial
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  At 1/4 MIC, apramycin reduces the growth rate of the test strains in the culture medium and induces a post-antibiotic effect lasting up to 5 hours. It inhibits A. pleuropneumoniae FMV 87-682 with an MIC50 of 8 mg/l. Apramycin significantly decreases the hemolytic activity of A. pleuropneumoniae and affects capsule production in this isolate and in a P. multocida isolate (type A). Misreading induced by apramycin, involving the incorporation of leucine, isoleucine, and serine, was detected, albeit limited to a narrow scope, in an E. coli cell-free system programmed with poly(U).
• In Vitro:
  Compared to untreated chicks, 225 mg/L Apramycin completely inhibited mortality and significantly reduced the excretion of Salmonella.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nebramycin II, inhibit, Inhibitor, Ai3-29795, 16S rRNA, Bacterial, Antibiotic, Apramycin, Apramycin sulfate, Apramycin Sulfate

Compound Identifiers

PubChem CID

3081544