Apramycin sulfate

SKU: orb1309823

Description

Apramycin sulfate

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 65710-07-8
• MW: 637.66
• Purity: 99.90%
• Formula: C₂₁H₄₃N₅O₁₅S
• SMILES: OS(O)(=O)=O.[H][C@]12C[C@@H](N)[C@@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)O[C@]1([H])[C@H](O)[C@H](NC)[C@@H](O[C@H]1O[C@H](CO)[C@@H](N)[C@H](O)[C@H]1O)O2
• Target: Antibacterial,Antibiotic
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  At 1/4 MIC, apramycin reduce the growth rate o the test strains in the culture medium and induces a post-antibiotic effect lasting up to 5 hours. It inhibits A. pleuropneumoniae mV 87-682 with an IC50 of 8 mg/l. Apramycin significantly decrease the hemolytic activity of A. pleuropneumoniae and affects capsule production in this isolate and in a P. multocida isolate (type A). Misreading induced by apramycin, involvin the incorporation of leucine, isoleucine, and serine, was detected, albeit limited to a narrow scope, in an E. coli cell-free system programmed with poly(U).
• In Vitro:
  Compared to untreated chicks, 225 mg/L Apramycin completely inhibited mortality and significantly reduce the excretion of Salmonella.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Nebramycin II, inhibit, Inhibitor, Ai3-29795, 16S rRNA, Bacterial, Antibiotic, Apramycin, Apramycin sulfate, Apramycin Sulfate

Compound Identifiers

PubChem CID

3081544