Apostatin-1

SKU: orb1685322

Description

Apostatin-1 (Apt-1) is a novel small molecule inhibitor that selectively targets the TRAF2-binding domain of TRADD. This mechanism enables its use in vitro and in vivo to investigate TNF signaling pathways, apoptosis, and necroptosis in relevant disease models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2559703-06-7
• MW: 345.5
• Purity: >99.99% (May vary between batches)
• Formula: C₁₉H₂₇N₃OS
• SMILES: CN1CCN=C1SC(C(=O)NC1CCCCCC1)c1ccccc1
• Target: Others,Necroptosis,RIP kinase,Apoptosis,Autophagy
• Solubility: Ethanol:9 mg/mL (26.05 mM);DMSO:50 mg/mL (144.72 mM)

Bioactivity

• In Vitro:
  Apostatin-1 inhibited bortezomib induced apoptosis and ripk1 dependent apoptosis (RDA) with the IC50 of ~1μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Necroptosis, inflammatory responses, inhibit, Jurkat cells, Inhibitor, HeLa, HT-29, beclin 1, Beclin1, Apoptosis, Apostatin 1, Apostatin1, Apostatin-1, Apt-1, Apt1, Apt 1, Autophagy, Atg6, TRADD, RIP kinase, RIPK1, RIPK, SH-SY5Y, Receptor-interacting protein kinases

Compound Identifiers

PubChem CID

154824620