Apostatin-1

SKU: orb1218272

Description

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.

Key Properties

• CAS Number: 2559703-06-7
• MW: 345.5
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₇N₃OS
• SMILES: O=C(NC1CCCCCC1)C(C2=CC=CC=C2)SC3=NCCN3C
• Target: TRADD
• Solubility: DMSO:65mg/ml(188.13mM; need ultrasonic); Ethanol:9mg/ml(26.06mM; need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Wild-type mice (n = 10, male, 8 weeks of age, systemic inflammation mouse model). Dosage: 20 mg/kg. Administration: IP, once. Result: Reduced expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns, including interferon γ (IFNγ), lipopolysaccharide (LPS), Pam3CSK4 (a synthetic bacterial lipopeptide), and muramyl dipeptide (MDP). Showed increased survival following intravenous delivery of TNF, a mouse model of systemic inflammation.
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• In Vitro:
  Western blot analysis. Cell line: SH-SY5Y, HeLa, HT-29, and Jurkat cells. Concentration: 10 μM. Incubation time: 6 h. Result: Effectively induced autophagy by LC3 II induction and p62 reduction.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apt-1

Quick Database Links

Gene Symbol

TRADD