APC Antibody

• Catalog Number: orb1731110
• Category: Antibodies
• Description: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
• Species/Host: Rabbit
• Clonality: Monoclonal
• Tested applications: ICC, IP, WB
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: A synthetic peptide of human APC
• Concentration: 1mg/ml
• Dilution range: IP: 1/20; WB: 1/500-1/1000; ICC: 1/50-1/200
• Conjugation: Unconjugated
• MW: Calculated MW: 312 kDa; Observed MW: 160 kDa
• Entrez: 324
• UniProt ID: P25054
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin
• Alternative names: APC; DP2.5; Adenomatous polyposis coli protein; Pr
• Note: For research use only
• Expiration Date: 12 months from date of receipt.