AOB2796

SKU: orb1222995

Description

AC-55541 is a protease-activated receptor (PAR) 2 agonist. AC-55541activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. AC-55541 was well absorbed when administered intraperitoneally to rats, each reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. AC-55541 may be useful in probing the physiological functions of PAR2 receptors.

Key Properties

• CAS Number: 916170-19-9
• MW: 518.36
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₀BrN₅O₃
• SMILES: C/C(=N\NC(=O)C(c1n[nH]c(=O)c2ccccc12)NC(=O)c1ccccc1)/c1cc(ccc1)Br
• Target: Protease-Activated Receptor 2
• Solubility: DMSO : ≥ 51 mg/mL;;98.39 mM

Bioactivity

• In Vitro:
  AC-55541 (100 nM; 1 hour) suppresses poly I: C-induced CXCL10 mRNA in NHBE cells. RT-PCR Cell line: NHBE cells. Concentration: 100 nM (prior to poly I: C stimulation). Incubation time: 1 hour. Result: Poly I: C-induced CXCL10 mRNA was suppressed.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC-55541 | AC 55541 | AC55541

Quick Database Links

Gene Symbol

Protease-Activated Receptor 2