PDCD1/PD-1/CD279 Antibody

SKU: orb1806321

Description

Anti-PDCD1 / PD-1 / CD279 Reference Antibody is expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Images & Validation

• Tested Applications: ELISA, FA, FACS, In vivo
• Reactivity: Human, Monkey, Primate

Key Properties

• Clonality: Monoclonal
• Target: PDCD1 / PD-1 / CD279
• Source/Expression System: CHO
• Molecular Weight: 143.44 kDa
• Purity: >95%
• Purification: Protein A
• Endotoxin: <0.001 EU/ug

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 100 mM Proline/Acetic acid 20mM Arginine pH 5.0
• Concentration: Batch dependent
• Disclaimer: For research use only

Anti-PDCD1 / PD-1 / CD279 Reference Antibody (pembrolizumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-PDCD1 / PD-1 / CD279 Reference Antibody (pembrolizumab)is more than 95% ;determined by SEC-HPLC.

Immobilized human PD 1 His at 2 μg/mL can bind Anti-PDCD1 / PD-1 / CD279 Reference Antibody (pembrolizumab);EC50=0.0039μg/mL.

Pembrolizumab inhibited the tumor growth of MC38 on human PD-1 mice. The result showed significant anti-tumor effects; with an tumor inhibition rate (TGI) of 44.0% at 0.18 mpk at D37.

Quick Database Links

Gene Symbol

PDCD1 / PD-1 / CD279

UniProt

Q15116