Anti-Influenza agent 4

SKU: orb2900578

Description

Anti-Influenza agent 4 is a potent and selective influenza virus inhibitor with EC50s of 150 nM and 62 nM for strains A/Roma and A/Parma, respectively.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 522625-85-0
• MW: 386.42
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₂O₅S
• SMILES: S(NCC1=CC=CO1)(=O)(=O)C2=CC(NC(=O)C3=CC=C(OC)C=C3)=CC=C2
• Target: Influenza Virus

Bioactivity

• In Vitro:
  Anti-Influenza agent 4 (compound 5) (0-500 μM; 24 and 48 h) exhibits low cytotoxicity in MDCK cells. Anti-Influenza agent 4 shows highly antiviral activity against influenza strain A/Roma and A/Parma with EC50s of 150±0.07 nM and 62±0.02 nM, respectively. Anti-Influenza agent 4 shows IC50s of 244 nM and 230.7 nM against influenza strain A/Roma and A/Parma in hemolysis inhibition assay. Cell Cytotoxicity Assay Cell line: MDCK cells. Concentration: 0-500 μM. Incubation time: 24 and 48 h. Result: Exhibited low cytotoxicity with a CC50 value of 450 μM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Influenza Virus