Anti-inflammatory agent 54

SKU: orb1944214

Description

Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-α, IL-6, and IL-1β. It effectively suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates in vivo efficacy in a mouse auricular edema model.

Key Properties

• CAS Number: 2924156-46-5
• MW: 328.32
• Formula: C₁₇H₁₆N₂O₅
• SMILES: C(CNC(/C=C/C1=CC=CO1)=O)N2C=3C(OC2=O)=CC(OC)=CC3
• Target: TNF,NO Synthase,NF-κB,Interleukin,Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TNF,NO Synthase,NF-κB,Interleukin,Others