CHLOROQUINE

SKU: orb1219657

Description

Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro with EC50 of 1.13 μM.Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased. Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro.Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54-05-7
• MW: 319.87
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₆ClN₃
• SMILES: CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• Target: HIV
• Solubility: DMSO:100 mg/mL (312.63 mM); Ethanol:100 mg/mL (312.63 mM; Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HIV