Anti-inflammatory agent 51

SKU: orb1944757

Description

Anti-inflammatory agent 51 is an amide/sulfonamide derivative that inhibits NF-κB activation, exhibiting anti-inflammatory and potential anti-tumor properties. It serves as a research tool for studying inflammatory diseases such as acute lung injury and ulcerative colitis in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2911610-03-0
• MW: 498.51
• Purity: 99.76% (May vary between batches)
• Formula: C₂₂H₂₂N₆O₆S
• SMILES: O=[N+]([O-])C1=CC=C(N2CCN(CC2)C3=CC=C(S(=O)(NCC4=NC=CC=C4)=O)C=C3[N+]([O-])=O)C=C1
• Target: NF-κB
• Solubility: DMSO:60 mg/mL (120.36 mM)

Bioactivity

• Target IC50:
  TNF-α:4.34 μM (J774A.1 cells)|IL-6:0.61 μM (J774A.1 cells)
• In Vivo:
  Anti-inflammatory agent 51 (compound 11d) mitigates lipopolysaccharide (LPS)-induced acute lung injury (ALI) and ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice .
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• In Vitro:
  Anti-inflammatory agent 51 (compound 11d) effectively reduces the release of IL-6 (IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM), decreases cytokine mRNA levels in J774A.1 cells, restores IκBα, and inhibits the nuclear translocation of phosphorylated p65 .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NFkB, NF-kB, NFκB, NF-κB, Antiinflammatoryagent51

Compound Identifiers

PubChem CID

167440168