Anti-inflammatory agent 55

SKU: orb1944213

Description

Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of iNOS, TNF-α, IL-6, and IL-1β. It notably suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 0.8 μM and demonstrates anti-inflammatory effects in vivo using a mouse auricular edema model.

Key Properties

• CAS Number: 2924156-51-2
• MW: 373.32
• Formula: C₁₇H₁₅N₃O₇
• SMILES: O=[N+](C1=CC=C(O1)/C=C/C(NCCN2C3=CC=C(OC)C=C3OC2=O)=O)[O-]
• Target: Interleukin,Others,TNF,NO Synthase,NF-κB

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,Others,TNF,NO Synthase,NF-κB