Anti-inflammatory agent 55

SKU: orb1944213

Description

Compound 9j, a Coixol derivative, is a potent anti-inflammatory small molecule that inhibits the NF-κB pathway. It suppresses pro-inflammatory mediators like iNOS, TNF-α, IL-6, and IL-1β in vitro (IC₅₀ = 0.8 μM for NO in RAW264.7 cells) and demonstrates efficacy in vivo in murine edema models.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2924156-51-2
• MW: 373.32
• Formula: C₁₇H₁₅N₃O₇
• SMILES: O=[N+](C1=CC=C(O1)/C=C/C(NCCN2C3=CC=C(OC)C=C3OC2=O)=O)[O-]
• Target: NF-κB,Interleukin,TNF,NO Synthase,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

167437624