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Catalog Number | orb1821019 |
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Category | Antibodies |
Description | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
Clonality | Monoclonal |
Clone Number | HM47 |
Tested applications | FC |
Reactivity | Bovine, Canine, Equine, Gallus, Guinea pig, Human, Mouse, Porcine, Primate, Rabbit, Rat |
Isotype | Mouse IgG1 kappa |
Immunogen | Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a |
Conjugation | FITC |
Target | CD79a |
Entrez | 973 |
UniProt ID | P11912 |
Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Buffer/Preservatives | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Alternative names | BCR alpha, Ig-alpha, MB-1, IGA Read more... |
Note | For research use only |
Application notes | Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining. |
Expiration Date | 12 months from date of receipt. |
Flow cytometry multicolor intracellular staining pattern of human lymphocytes using anti-human CD79a (HM47) FITC antibody (4 μl reagent / 100 μl of peripheral whole blood) and anti-human CD19 (LT19) APC antibody (10 μl reagent / 100 μl of peripheral whole blood).
Separation of human CD19 positive CD79a positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD79a (HM47) FITC antibody (4 μl reagent / 100 μl of peripheral whole blood).
Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human CD79a (HM47) FITC antibody (4 μl reagent / 100 μl of peripheral whole blood).
FC | |
Bovine, Equine, Gallus, Guinea pig, Human, Mouse, Opossum, Porcine, Rabbit, Rat | |
Monoclonal | |
FITC |