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Anti-Hu CD79a Biotin
Catalog Number: orb2653062
| Catalog Number | orb2653062 |
|---|---|
| Category | Antibodies |
| Description | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
| Clonality | Monoclonal |
| Clone Number | ZL7.4 |
| Tested applications | ELISA, FC, ICC, IHC-P, IP |
| Reactivity | Human |
| Isotype | Mouse IgG1 kappa |
| Immunogen | IgM complex isolated from Daudi cells |
| Concentration | 1 mg/ml |
| Conjugation | Biotin |
| Target | CD79a |
| Entrez | 973 |
| UniProt ID | P11912 |
| Storage | Store at 2-8°C. Do not freeze. |
| Buffer/Preservatives | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Alternative names | BCR alpha, Ig-alpha, MB-1, IGA Read more... |
| Note | For research use only |
| Application notes | Flow cytometry: Recommended dilution: 1-5 μg/ml. |
| Expiration Date | 12 months from date of receipt. |
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD79a (ZL7.4) Biotin antibody (concentration in sample 5 μg/ml, Streptavidin APC).
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD79a (ZL7.4) Biotin antibody (concentration in sample 5 μg/ml, Streptavidin APC).
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD79a (ZL7.4) Biotin antibody (concentration in sample 5 μg/ml, Streptavidin APC).
