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Anti-Hu CD272 Purified
Catalog Number: orb1088502
| Catalog Number | orb1088502 |
|---|---|
| Category | Antibodies |
| Description | CD272, a type I transmembrane glycoprotein, contains in its intracellular domain two ITIM sequences, which are upon CD272 triggering phosphorylated and recruit SHP phosphatases to attenuate cell activation. CD272 is expressed on B and T lymphocytes, NK cells, dendritic cells, and macrophages, and its ligand is CD270. Defects in CD272-CD270 inhibitory mechanism lead to autoimmune diseases. Overexpression of CD272 is a marker of tolerant T cells. |
| Clonality | Monoclonal |
| Clone Number | MIH26 |
| Tested applications | FC |
| Reactivity | Human, Primate |
| Isotype | Mouse IgG2a kappa |
| Immunogen | cells transfected with human CD272 |
| Antibody Type | Primary Antibody |
| Concentration | 1 mg/ml |
| Purity | Purified by protein-A affinity chromatography. |
| Conjugation | Unconjugated |
| Target | CD272 |
| Entrez | 151888 |
| UniProt ID | Q7Z6A9 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Alternative names | Anti-BTLA1 antibody Read more... |
| Note | For research use only |
| Application notes | Flow cytometry: Recommended dilution: 2-5 μg/ml. |
| Expiration Date | 12 months from date of receipt. |
Separation of human CD272 positive lymphocytes (red-filled) from human neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of peripheral whole blood stained using anti-human CD272 (MIH26) purified antibody (concentration in sample 1.7 μg/ml, GAM APC).
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD272 (MIH26) purified antibody (concentration in sample 1.7 μg/ml, GAM APC).
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