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Anti-Hu CD24 Biotin
Catalog Number: orb2653064
| Catalog Number | orb2653064 |
|---|---|
| Category | Antibodies |
| Description | CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid. |
| Target | CD24 |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Conjugation | Biotin |
| Reactivity | Human |
| Concentration | 1 mg/ml |
| Buffer/Preservatives | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Immunogen | Glycoproteins purified from human NALM-1 cell line. |
| UniProt ID | P25063 |
| Tested applications | FC, IHC-Fr |
| Application notes | Flow cytometry: Recommended dilution: 1-5 μg/ml. |
| Clone Number | SN3 |
| Storage | Store at 2-8°C. Do not freeze. |
| Alternative names | HSA, nectadorin, SCLC4 |
| Note | For research use only |
| Entrez | 100133941 |
| Expiration Date | 12 months from date of receipt. |
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD24 (SN3) Biotin antibody (concentration in sample 5 μg/ml, Streptavidin APC).
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD24 (SN3) Biotin antibody (concentration in sample 5 μg/ml, Streptavidin APC).
