CD118 Antibody

• Catalog Number: orb1147811
• Category: Antibodies
• Description: CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.
• Target: CD118
• Clonality: Monoclonal
• Isotype: Mouse IgG1 kappa
• Conjugation: Unconjugated
• Reactivity: Human
• Concentration: 1 mg/ml
• Buffer/Preservatives: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Purification: Purified by protein-A affinity chromatography.
• Immunogen: human recombinant soluble CD118-Fc
• UniProt ID: P42702
• Tested applications: ELISA, FC, WB
• Application notes: Flow cytometry: Recommended dilution: 2-5 μg/ml.
• Antibody Type: Primary Antibody
• Clone Number: 12D3
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: LIFR alpha, SWS, SJS2, STWSm, gp190
• Research Area: Epigenetics
• Note: For research use only
• Entrez: 3977
• Expiration Date: 12 months from date of receipt.

Separation of JAR cells stained using anti-human CD118 (12D3) purified antibody (concentration in sample 5 μg/ml, GAM APC, red-filled) from JAR cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining) of JAR cell suspension.