CD118 Antibody (PE)

• Catalog Number: orb1806411
• Category: Antibodies
• Description: CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.
• Target: CD118
• Clonality: Monoclonal
• Isotype: Mouse IgG1 kappa
• Conjugation: PE
• Reactivity: Human
• Concentration: 0.1 mg/ml
• Buffer/Preservatives: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
• Immunogen: human recombinant soluble CD118-Fc
• UniProt ID: P42702
• Tested applications: FC
• Application notes: Flow cytometry: Recommended dilution: 4-10 μg/ml.
• Clone Number: 12D3
• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Alternative names: LIFR alpha, SWS, SJS2, STWSm, gp190
• Note: For research use only
• Entrez: 3977
• Expiration Date: 12 months from date of receipt.

Separation of JAR cells stained using anti-human CD118 (12D3) PE antibody (concentration in sample 15 μg/ml, red-filled) from JAR cells stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 15 μg/ml, same as CD118 PE concentration, black-dashed) in flow cytometry analysis (surface staining) of JAR cell suspension.