CD105 Antibody (Biotin)

SKU: orb154464

Description

Mouse monoclonal antibody conjugated to Biotin which recognizes CD105 that also known as Endoglin, is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1). It is a major glycoprotein of vascular endothelium. It may play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.

Research Area

Cancer, Cardiovascular Disease, Epigenetics

Images & Validation

• Tested Applications: FC, ICC, IHC-Fr, WB
• Reactivity: Human, Porcine
• Application Notes:
  Flow cytometry: Recommended dilution: 8 μg/ml; positive control: Kg1 human acute myelogenous leukemia cell line.

Key Properties

• Antibody Type: Primary Antibody
• Clonality: Monoclonal
• Isotype: Mouse IgG2a
• Clone No.: MEM-229
• Immunogen: Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
• Target: CD105
• Purification: Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
• Conjugation: Biotin

Storage & Handling

• Storage: Store at 2-8°C. Do not freeze.
• Buffer/Preservatives: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endoglin, END, ENG, HHT1, ORW1

Flow cytometry analysis (surface staining) of CD105 on Huvec and HEK-293 cells with anti-CD105 (MEM-229) biotin.

Quick Database Links

Gene Symbol

CD105

UniProt

P17813

NCBI Gene ID

2022