Granzyme B GZMB Rabbit Monoclonal Antibody

SKU: orb547267

Description

Anti-Granzyme B GZMB Monoclonal Antibody. Tested in IHC, ICC/IF, IP applications. This antibody reacts with Human.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

• Tested Applications: ICC, IF, IHC, IP
• Dilution Range: IHC 1:50-1:200 ICC/IF 1:50-1:200 IP 1:50
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone No.: AAHC-7
• Immunogen: A synthesized peptide derived from human Granzyme B This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
• Target: Granzyme B
• Molecular Weight: 23 kDa
• Purification: Affinity-chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. *This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.
• Concentration: 0.5mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB, OBR

IHC analysis of GZMB using anti-GZMB antibody on paraffin-embedded human T cell lymphoma.GZMB was detected in paraffin-embedded section.

Quick Database Links

Gene Symbol

Granzyme B

UniProt

P10144