Anti-Granzyme B GZMB Monoclonal Antibody

• Catalog Number: orb547267
• Category: Antibodies
• Description: Anti-Granzyme B GZMB Monoclonal Antibody. Tested in IHC, ICC/IF, IP applications. This antibody reacts with Human.
• Species/Host: Rabbit
• Clonality: Monoclonal
• Clone Number: AAHC-7
• Tested applications: ICC, IF, IHC, IP
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: A synthesized peptide derived from human Granzyme B This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
• Antibody Type: Primary Antibody
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form/Appearance: Liquid
• Conjugation: Unconjugated
• MW: 23 kDa
• UniProt ID: P10144
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: Leptin receptor; LEP-R; HuB219; OB receptor; OB-R;
• Note: For research use only
• Application notes: IHC 1:50-1:200ICC/IF 1:50-1:200IP 1:50. Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Expiration Date: 12 months from date of receipt.

IHC analysis of GZMB using anti-GZMB antibody on paraffin-embedded human T cell lymphoma.GZMB was detected in paraffin-embedded section.