Anti-AXL / UFO Reference Antibody (tilvestamab)

• Catalog Number: orb1805936
• Category: Antibodies
• Description: Anti-AXL / UFO Reference Antibody is expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 146.16 kDa.
• Clonality: Monoclonal
• Tested applications: ELISA, FA, FACS, Kinetics
• Reactivity: Human
• Isotype: IgG
• Purity: > 95%
• Conjugation: Unconjugated
• MW: 146.16 kDa
• Target: AXL / UFO
• Endotoxins: < 1 EU/mg
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 100 mM Pro-Ac 20 mM Arg pH 5.0
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Anti-AXL / UFO Reference Antibody (tilvestamab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-AXL / UFO Reference Antibody (tilvestamab)is more than 95% ;determined by SEC-HPLC.

Immobilized human Axl FC at 2 μg/mL can bind Anti-AXL / UFO Reference Antibody (tilvestamab);EC50=0.01542μg/mL.

Human AXL HEK293 cells were stained with Anti-AXL / UFO Reference Antibody (tilvestamab) and negative control protein respectively; washed and then followed by PE and analyzed with FACS; EC127=0.07318 μg/mL.

The endocytosis ratio tilvestamab by U251 increased with the increase of antibody concentration; and the Internalization Rate (%) reached 40% at antibody concentration of 1 nM.

Anti-AXL / UFO Reference Antibody (tilvestamab) P-AKT Test was evaluated using U251 cell. The max induction fold was approximately 1.43.