ASC Rabbit Polyclonal Antibody

SKU: orb338943

Description

The ASC Antibody is suitable for IF, IHC, WB. It is a Polyclonal, Unconjugated antibody which raised against KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASC. The exact sequence is proprietary. Purification: The antibody was purified by immunogen affinity chromatography.

Research Area

Apoptotic, Cancer, Epigenetics, Immunology, Neuroscience, Signaling Pathways

Images & Validation

• Tested Applications: IF, IHC, WB
• Dilution Range: WB: 1:500-1000, IHC-P: 1:100-200, IF/ICC: 1:100-500
• Reactivity: Human, Mouse, Rat

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASC. The exact sequence is proprietary.
• Target: PYCARD
• Purification: The antibody was purified by immunogen affinity chromatography.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1

Quick Database Links

Gene Symbol

PYCARD

UniProt

Q9ULZ3, Q9EPB4

NCBI Gene ID

66824, 29108

Jun Sun 1, Qiuhua Zeng 2, Zhimin Wu 3, Lixin Huang 3, Tao Sun 3, Cong Ling 3, Baoyu Zhang 3, Chuan Chen 4, Hui Wang Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration Neurotherapeutics, 2, e00347 (2024)

PubMed: 38570276

Applications

WB

Reactivity

Mouse

Xiaolan Huang 1, Xiangmin Luo 2, Suzhen Huang 2, Xiaoqing Chen 3, Lingling Qiu 2 Inhibition of FoxO1 alleviates polycystic ovarian syndrome by reducing inflammation and the immune response Funct Integr Genomics, (2024)

PubMed: 38189995

Applications

WB

Reactivity

Rat

Jia Shen 1, Xiaojun Ma Inhibition of the Foxo3/Txnip Axis Alleviates Ventilator-Induced Diaphragmatic Dysfunction by Downregulating MuRF1 Appl Biochem Biotechnol, (2025)

PubMed: 40377847

Applications

WB

Reactivity

Mouse

Sebastian Vogel et al. NLRP3 inflammasome-mediated platelet hyperreactivity in sickle cell mice is targetable by BTK inhibition Biochemical and Biophysical Research Communications,

PubMed: 41643555

Applications

IF

Reactivity

Mouse