Anifrolumab Antibody

SKU: orb1944782

Description

Anifrolumab (MEDI-546) is a human monoclonal antibody that acts as a potent antagonist of the type I interferon receptor. It is applied in research for systemic lupus erythematosus (SLE), with studies demonstrating its ability to inhibit IFN signaling in both in vitro assays and in vivo preclinical models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1326232-46-5
• MW: 144.92 kDa
• Purity: > 95%
• Target: IFNAR
• Solubility: DMSO:60 mg/mL

Bioactivity

• Target IC50:
  ISRE:0.3 nM
• In Vitro:
  Anifrolumab induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation at a concentration of 67.7 nM for 20 minutes. Anifrolumab suppresses the differentiation of B cells into plasma cells at concentrations of 1 and 10 μg/mL for 6 or 7 days. Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively.At a concentration of 67.7 nM, Anifrolumab dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MEDI546, MEDI-546, MEDI 546, MDX1333, MDX-1333, MDX 1333, IFNAR, Anifrolumab

Quick Database Links

Gene Symbol

IFNAR