Andrograpanin

SKU: orb1298271

Description

Andrograpanin is a bioactive labdane diterpenoid isolated from Andrographis paniculata. It exhibits documented anti-inflammatory and anti-infectious properties, making it a compound of interest for research in immunology and infectious disease, including in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 82209-74-3
• MW: 318.45
• Purity: 99.46% (May vary between batches)
• Formula: C₂₀H₃₀O₃
• SMILES: [H][C@]12CCC(=C)[C@@H](CCC3=CCOC3=O)[C@]1(C)CCC[C@@]2(C)CO
• Target: p38 MAPK
• Solubility: DMSO:55 mg/mL (172.71 mM)

Bioactivity

• In Vitro:
  Andrograpanin boosts the movement of leukocytes towards higher concentrations of the chemokine SDF-1α in Jurkat, THP-1, and PBL cells, demonstrating its ability to enhance chemotaxis. Additionally, it exhibits anti-inflammatory effects by inhibiting the p38 MAPKs signaling pathways in macrophage cells stimulated with lipopolysaccharide.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

chemotaxis, 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE, Andrograpanin, anti-inflammatory, PBL, inhibit, Inhibitor, Jurkat, leukocyte, p38 MAPK, p38MAPK, THP-1, SDF-1α

Compound Identifiers

PubChem CID

11666871