Anamorelin

SKU: orb1310000

Description

Anamorelin (ONO-7643) is a potent and selective ghrelin receptor agonist, demonstrating an EC50 of 0.74 nM in FLIPR-based assays. It is utilized in research on cancer cachexia, appetite stimulation, and muscle wasting, with applications in both in vitro mechanistic studies and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 249921-19-5
• MW: 546.7
• Purity: 99.35%
• Formula: C₃₁H₄₂N₆O₃
• SMILES: CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
• Target: GHSR
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.66 mM);DMSO:250 mg/mL (457.29 mM)

Bioactivity

• Target IC50:
  Ghrelin receptor:（EC50）0.74 nM |Ghrelin receptor:（ki）0.7 nM
• In Vivo:
  Anamorelin(ANAM) showed significant agonist and binding activity on the ghrelin receptor, and stimulated GH release in vitro. In rats, ANAM significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses. Increases in GH and IGF-1 levels were observed following ANAM administration in pigs.
• In Vitro:
  Anamorelin(ANAM) is a potent and highly specific ghrelin receptor agonist

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anamorelin, inhibit, ONO 7643, ONO7643, ONO-7643, Inhibitor, Growth hormone secretagogue receptor, GHSR, GHS-R, ghrelin receptor, RC1291, RC-1291, RC 1291

Compound Identifiers

PubChem CID

9828911