AnaMorelin hydrochloride

SKU: orb1299963

Description

AnaMorelin hydrochloride (RC-1291 hydrochloride) is a potent and selective ghrelin receptor agonist, demonstrating an EC50 of 0.74 nM in FLIPR-based calcium mobilization assays. This compound is a valuable research tool for investigating ghrelin signaling in studies of appetite regulation, cachexia, and growth hormone secretion in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 861998-00-7
• MW: 583.16
• Purity: 99.18%
• Formula: C₃₁H₄₃ClN₆O₃
• SMILES: Cl.[H][C@](Cc1c[nH]c2ccccc12)(NC(=O)C(C)(C)N)C(=O)N1CCC[C@@](Cc2ccccc2)(C1)C(=O)N(C)N(C)C
• Target: GHSR
• Solubility: H2O:50 mg/mL (85.74 mM);DMSO:28 mg/mL (48.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.43 mM)

Bioactivity

• Target IC50:
  Ghrelin receptor (FLIPR assay):0.74 nM(EC50)
• In Vivo:
  In rats, AnaMorelin hydrochloride(ANAM) significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses. Increases in GH and IGF-1 levels were observed following ANAM administration in pigs.
• Animal Research:
  Fluorescent imaging plate reader and binding assays in HEK293 and baby hamster kidney cells determined the agonist and antagonist activity of ANAM, and its affinity for the ghrelin receptor. Rat pituitary cells were incubated with ANAM to evaluate its effect on growth hormone (GH) release. In vivo, rats were treated with ANAM 3, 10, or 30 mg/kg, or control orally, once daily for 6 days to evaluate the effect on food intake (FI) and body weight (BW), and once to assess GH response. In pigs, single (3.5 mg/kg) or continuous (1 mg/kg/day) ANAM doses were administered to assess GH and insulin-like growth factor (IGF-1) response.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ghrelin receptor, GHSR, GHS-R, Growth hormone secretagogue receptor, Inhibitor, inhibit, ONO7643 Hydrochloride, ONO-7643 hydrochloride, ONO-7643 Hydrochloride, ONO7643, ONO-7643, ONO 7643 Hydrochloride, ONO 7643, Anamorelin, AnaMorelin Hydrochloride, AnaMorelin hydrochloride, RC 1291, RC 1291 Hydrochloride, RC-1291, RC1291 Hydrochloride, RC-1291 hydrochloride, RC-1291 Hydrochloride, RC1291

Compound Identifiers

PubChem CID

16072155