Anagrelide hydrochloride

SKU: orb1300810

Description

Anagrelide hydrochloride is a small molecule inhibitor used in research to study essential thrombocythemia. It functions by reducing platelet production and is applied in both in vitro and in vivo studies of myeloproliferative disorders and megakaryocyte differentiation.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 58579-51-4
• MW: 292.55
• Purity: 99.77%
• Formula: C₁₀H₇Cl₂N₃O·HCl
• SMILES: Cl.Clc1ccc2NC3=NC(=O)CN3Cc2c1Cl
• Target: PDE,Apoptosis
• Solubility: DMSO:2.97 mg/mL (10.15 mM)

Bioactivity

• In Vitro:
  Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Agrylin, Anagrelide Hydrochloride, Anagrelide, Anagrelide HCl, Anagrelide hydrochloride, BL4162A, BMY 26538-01, Inhibitor, inhibit, PDE, phosphodiesterase, Phosphodiesterase (PDE)

Compound Identifiers

PubChem CID

135413494