Anagrelide HCl

SKU: orb1222002

Description

Anagrelide hydrochloride, also known as Agrylin, is a drug used for the treatment of essential thrombocytosis---overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. Anagrelide controlled release (GALE-401) is in phase III clinical trials by Galena Biopharma for the treatment of essential thrombocytosis.

Key Properties

• CAS Number: 58579-51-4
• MW: 292.55
• Purity: >98% (HPLC)
• Formula: C₁₀H₇Cl₂N₃O·HCl
• SMILES: Cl.ClC1=CC=C2NC3=NC(=O)CN3CC2=C1Cl
• Target: HIV
• Solubility: DMSO : 7.69 mg/mL 26.29 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model. Dosage: 5 mg/kg. Administration: Twice daily; for 10 days. Result: Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
• In Vitro:
  Cell Viability Assay Cell line: Megakaryocytic and non-megakaryocytic cells. Concentration: 0.05, 0.3, 1 μM Incubation time: 12-day. Result: Inhibited only megakaryocytic cell growth at every concentration tested. Cell Cytotoxicity Assay Cell line: GIST882 and GIST48 cell line. Concentration: 0.1, 1, 10, 100, 1000, 10000 nM Incubation time: Result: Induced a cytotoxic effect in the GIST882 cell line (IC50 = 16 nM), but was only weakly active in the GIST48 cell line.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anagrelide hydrochloride | BL 4162A | GALE-401 | Thromboreductin

Quick Database Links

Gene Symbol

HIV