ANA-12

SKU: orb1223183

Description

ANA-12 is aTrkB receptor antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA-12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans. ANA-12 may be a valuable tool for studying BDNF/TrkB signaling and may constitute a lead compound for developing the next generation of therapeutic agents for the treatment of mood disorders.

Key Properties

• CAS Number: 219766-25-3
• MW: 407.49
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₁N₃O₃S
• SMILES: O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1
• Target: LTR
• Solubility: DMSO : 9.09 mg/mL. 22.31 mM;H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ANA12 | ANA 12 | ANA-12

Quick Database Links

Gene Symbol

LTR