AN-2690

SKU: orb1225930

Description

An antifungal compound that inhibits cytoplasmic leucyl-tRNA synthetase for the potential treatment of nnychomycosis; inhibits T. rubrum, T. mentagrophytes, C. albicans, C. neoformans with MIC50s of 0.25-1ug/mL.(In Vitro):Tavaborole (AN-2690) shows an 8-fold increase in activity against C. neoformans, and an 8-fold increase in activity against A. fumigatus. Tavaborole (AN-2690) obviously inhibit the cells expressing GlLeuRS-D444A, but has no effect on the cells expressing GlLeuRS and GlLeuRS-D444E.

Key Properties

• CAS Number: 174671-46-6
• MW: 151.9307
• Purity: >98% (HPLC)
• Formula: C₇H₆BFO₂
• SMILES: OB1OCC2=CC(F)=CC=C12
• Target: Fungal
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  Tavaborole (AN-2690) shows an 8-fold increase in activity against C. neoformans, and an 8-fold increase in activity against A. fumigatus. Tavaborole (AN-2690) obviously inhibit the cells expressing GlLeuRS-D444A, but has no effect on the cells expressing GlLeuRS and GlLeuRS-D444E.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tavaborole | AN2690 | AN 2690

Quick Database Links

Gene Symbol

Fungal