Amyloid Oligomers (A11) Antibody (FITC)

SKU: orb152854

Description

Rabbit polyclonal to Amyloid Oligomers (FITC). Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres. These include the amyloid- beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimers symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinsons disease, and accumulation of polyglutamine-containing aggregates in Huntingtons disease.

Images & Validation

• Tested Applications: ELISA, ICC, IF, IHC, IP, WB
• Dilution range: The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100
• Reactivity: Human, Mouse, Other, Rat
• Application Notes:
  A 1:200 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 µg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic molecular mimic of soluble oligomers
• Target: Amyloid Oligomers (A11)
• Purification: Protein A Purified
• Conjugation: FITC

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
• Disclaimer: For research use only

Alternative Names

Amyloid Oligomer alpha beta, A11, Amyloid Oligomer AlphaBeta, APP, Amyloid beta A4 protein, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, A4, AD1

Immunohistochemistry analysis using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody. Tissue: Alzheimer's Disease brain. Species: Human. Fixation: Formalin fixed. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody at 1:1000. Secondary Antibody: Goat Anti-Rabbit ATTO 594 (red). Localization: Plaque. (A) Amyloid Fibril (OC) Antibody. (B) Amyloid Oligomer (A11) Antibody. (C) Composite.

Western blot analysis of Human Abeta42 fibrils and prefibrillar oligomers showing detection of Amyloid Oligomers (A11) protein using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody at 1:1000.

Dot blot analysis using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody. Tissue: Abeta42 fibrils and prefibrillar oligomers. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody at 1:1000.

Quick Database Links

Gene Symbol

Amyloid Oligomers (A11)

UniProt

P05067

NCBI Gene ID

8666

RefSeq (mRNA):NM_000484.2