AMPK-IN-3

SKU: orb1687298

Description

AMPK-IN-3 is a selective and potent small molecule inhibitor of AMPK (α2 and α1 isoforms) and KDR, with respective IC50 values of 60.7 nM, 107 nM, and 3820 nM. It has demonstrated anticancer activity in vitro against K562 leukemia cells, making it a useful research tool for studying AMPK signaling in oncology and metabolic research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2417674-27-0
• MW: 451.56
• Purity: 97.25% (May vary between batches)
• Formula: C₂₅H₃₃N₅O₃
• SMILES: CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC(N)=O)cc23)c1C
• Target: VEGFR,AMPK
• Solubility: DMSO:50 mg/mL (110.73 mM)

Bioactivity

• Target IC50:
  KDR:3820 nM|AMPK α2:60.7 nM|AMPK α1:107 nM
• In Vitro:
  At a concentration of 100 nM, AMPK-IN-3 exhibits inhibition values of 64%, 43%, 41%, and 29% for AMPK(α2), FLT1, JAK1 JH2-pseudokinase, and AMPK(α1), respectively.In K562 cells, AMPK-IN-3, when applied at concentrations of 0.195313, 0.78125, 3.125, 12.5, and 50 µM for 2 hours, reduces the level of p-ACC. For a duration of 24, 48, and 72 hours, AMPK-IN-3, within the concentration range of 1-100 µM, demonstrates potent inhibition of cellular AMPK activity without affecting cell viability.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, KDR

Compound Identifiers

PubChem CID

162664520