Amodiaquine hydrochloride

• Catalog Number: orb1909163
• Category: Small Molecules
• Description: Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, is an antimalarial agent that also acts as a potent oral histamine N-methyltransferase inhibitor with a K i value of 18.6 nM. Additionally, it functions as a Nurr1 agonist, targeting the Nurr1-LBD (ligand binding domain) with an EC 50 of approximately 20 μM, demonstrating anti-inflammatory effects [1] [2] [3] [4] [5].
• Purity: 98.00%
• MW: 428.78
• Biological Activity: Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, serves as an antimalarial agent and exhibits potent oral activity as a histamine N-methyltransferase inhibitor, displaying a K i value of 18.6 nM. Additionally, it acts as a Nurr1 agonist, targeting the Nurr1-LBD (ligand binding domain) with an EC 50 of approximately 20 μM, thereby demonstrating an anti-inflammatory effect [1] [2] [3] [4] [5].
• CAS Number: 69-44-3
• Formula: C₂₀H₂₄Cl₃N₃O
• SMILES: CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.Cl.Cl
• Storage: -20°C
• Note: For research use only