Amodiaquine dihydrochloride dihydrate

SKU: orb1310667

Description

Amodiaquine dihydrochloride dihydrate

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6398-98-7
• MW: 464.82
• Purity: 99.90% (May vary between batches)
• Formula: C₂₀H₂₈Cl₃N₃O₃
• SMILES: O.Cl.CCN(CC)Cc1c(O)ccc(Nc2c3ccc(Cl)cc3ncc2)c1.O.Cl
• Target: Histone Methyltransferase,Parasite,Histamine Receptor,NR4A
• Solubility: H2O:27 mg/mL (58.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM);DMSO:85 mg/mL (182.87 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Histamine N-methyl transferase:18.6 nM(Ki)
• In Vivo:
  In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXCL2, Amodiaquin, Amodiaquin dihydrochloride Dihydrate, Amodiaquin dihydrochloride dihydrate, Amodiaquine, Amodiaquine dihydrochloride dihydrate, Amodiaquine dihydrochloride Dihydrate, Amodiaquine hydrochloride, Amodiaquine Hydrochloride, antimalarial, anti-inflammatory, CCL2, HistamineReceptor, Histamine Receptor, Histone Methyltransferase, HistoneMethyltransferase, histamine N-methyl transferase, Inhibitor, Nurr1, N-methyltransferase, neuroprotective, Parasite, IL-1β, inhibit

Compound Identifiers

PubChem CID

64646