Amlodipine Besylate

SKU: orb1226970

Description

Amlodipine Besylate is a long-acting calcium channel blocker.(In Vitro):Amlodipine besylate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine besylate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.Amlodipine besylate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.(In Vivo):Amlodipine besylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.Amlodipine besylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 111470-99-6
• MW: 567.05
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₁ClN₂O₈S
• SMILES: O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O
• Target: Calcium Channel
• Solubility: Ethanol: 14 mg/mL (24.68 mM); DMSO: 113 mg/mL (199.27 mM)

Bioactivity

• In Vivo:
  Amlodipine besylate (5 mg/kg/day; s. c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice. Amlodipine besylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice. Animal model: ATP2B1loxP/loxP mice. Dosage: 5 mg/kg/day. Administration: Subcutaneously implanted osmotic pump for 2 weeks. Result: Significantly decreased the blood pressure.
• In Vitro:
  Amlodipine besylate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively. Amlodipine besylate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells. Amlodipine besylate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amlodipine besylate | Cardiorex | Cordarene

Quick Database Links

Gene Symbol

Calcium Channel