Aminoguanidine hydrochloride

SKU: orb1310691

Description

Aminoguanidine hydrochloride is a selective inhibitor of diamine oxidase and nitric oxide synthase. It is widely used in research on diabetic complications, particularly nephropathy, and has been employed in both in vitro enzymatic studies and in vivo animal models of diabetes.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1937-19-5
• MW: 110.55
• Purity: >99.99% (May vary between batches)
• Formula: CH₆N₄·HCl
• SMILES: Cl.NNC(N)=N
• Target: NO Synthase,Apoptosis,NOS
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:247 mg/mL (2234.28 mM);H2O:20 mg/mL (180.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (45.23 mM)

Bioactivity

• In Vivo:
  Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aminoguanidine, Aminoguanidinium, Guanyl hydrazine, Guanylhydrazine hydrochloride, Hydrazinecarboximidamide, GER 11, GER11, GER-11, Imino semicarbazide, iNOS, NOSynthase, NO Synthase, Pimagedine hydrochloride

Compound Identifiers

PubChem CID

2734687