Aminoguanidine hydrochloride

SKU: orb1225799

Description

Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy.

Key Properties

• CAS Number: 1937-19-5
• MW: 110.55
• Purity: >98% (HPLC)
• Formula: CH₆N₄·HCl
• SMILES: Cl.NN=C(N)N
• Target: NOS
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Animal model: Male Swiss albino mice. Dosage: 50 mg/kg. Administration: Intraperitoneally 30 min before the administration of CCl4. Result: Inhibited the serum AST level and protected hepatotoxin-induced lipid peroxidation. Animal model: Adult male Wistar rats. Dosage: 200 mg/kg. Administration: Intraperitoneally 1 hour before the administration of CP and killed 16 hours after CP injection. Result: Attenuated CP-induced MDA elevation and prevented CP-induced protein oxidation. Restored the GSH levels and attenuated CP-induced increase in MPO activity.
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• In Vitro:
  Apoptosis Analysis Cell line: A549. Concentration: 100-1000 μM. Incubation time: 24 h. Result: Showed protective effect on DOX-induced DNA damage and decreased DOX-induced apoptosis. Cell Proliferation Assay Cell line: AR42J. Concentration: 100 μM. Incubation time: 24-96 h. Result: Showed a significant increase in cell proliferation after incubation for 48 h.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aminoguanidinium chloride | GER 11 | Pimagedine

Quick Database Links

Gene Symbol

NOS