Amino-PEG11-amine

SKU: orb1308662

Description

This bifunctional PEG linker enables the conjugation of two diethylstilbestrol (DES) ligands, creating potent and selective estrogen receptor (ER) antagonists for breast cancer research. It is used in the development of novel endocrine therapies, with applications in both in vitro receptor binding assays and in vivo pharmacological studies.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 479200-82-3
• MW: 544.677
• Purity: 95.00% (May vary between batches)
• Formula: C₂₄H₅₂N₂O₁₁
• SMILES: NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
• Target: PROTAC Linker
• Solubility: DMSO:10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.67 mM)

Bioactivity

• In Vitro:
  PROTACs are bifunctional molecules consisting of two ligands linked together: one ligand targets an E3 ubiquitin ligase and the other targets the specific protein to be degraded. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AminoPEG11amine, Amino-PEG-11-amine, Amino-PEG11-amine, Amino PEG11 amine, Inhibitor, inhibit, PROTAC Linker, PROTAC Linkers, PROTACLinker, PEGs

Compound Identifiers

PubChem CID

77078167