Amino-PEG11-amine

SKU: orb1217998

Description

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

Research Area

Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	479200-82-3
MW	544.68
Purity	>98% (HPLC)
Formula	C₂₄H₅₂N₂O₁₁
SMILES	NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Target	PROTAC
Solubility	DMSO:10 mM

Bioactivity

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In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

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Quick Database Links

Gene Symbol

PROTAC

Protocol Information

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Purity:	95.00% (May vary between batches)
CAS Number:	479200-82-3
MW:	544.677
Formula:	C₂₄H₅₂N₂O₁₁