Amino-PEG11-amine

SKU: orb1217998

Description

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 479200-82-3
• MW: 544.68
• Purity: >98% (HPLC)
• Formula: C₂₄H₅₂N₂O₁₁
• SMILES: NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
• Target: PROTAC
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTAC