AMG-25

SKU: orb1704855

Description

AMG-25 (c-Kit-IN-5-1) is a potent, selective c-Kit inhibitor with additional activity against KDR, p38, Lck, and Src kinases. It serves as a valuable research tool for investigating mast cell-driven pathologies, including fibrosis, in both cellular and animal model studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1003311-62-3
• MW: 395.41
• Purity: 98.16% (May vary between batches)
• Formula: C₂₃H₁₇N₅O₂
• SMILES: Cc1ccn(-c2ccc(cc2)-c2ncco2)c(=O)c1-c1ccc2nc(N)ncc2c1
• Target: c-Kit
• Solubility: DMSO:20 mg/mL (50.58 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCFR, CD117, cKit, c-Kit, cKitIN51, c-Kit-IN-5-1, 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one, 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one, AMG 25, AMG25, AMG-25, c Kit IN 5 1, mast, fibrotic

Compound Identifiers

PubChem CID

24879368