AMG-25

SKU: orb1219201

Description

AMG-25 is a novel selective and potent c-Kit inhibitor.

Key Properties

• CAS Number: 1003311-62-3
• MW: 395.41
• Purity: >98% (HPLC)
• Formula: C₂₃H₁₇N₅O₂
• SMILES: CC(C=CN1c(cc2)ccc2-c2ncco2)=C(c2cc3cnc(N)nc3cc2)C1=O
• Target: c-Kit
• Solubility: In Vitro: DMSO : 25 mg/mL (63.23 mM)

Bioactivity

• In Vivo:
  c-Kit-IN-5 (compound 25) (1 mg/kg; i. v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats. c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats.
• In Vitro:
  c-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50 = >5.0, 40, 7.8, and >5.0 μM, respectively).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one

Quick Database Links

Gene Symbol

c-Kit