AMAROGENTIN

SKU: orb1301740

Description

Amarogentin is a natural secoiridoid glycoside primarily sourced from Swertia and Gentiana species. It exhibits chemopreventive potential in liver cancer models by regulating cell cycle progression and inducing apoptosis, as demonstrated in both in vitro and in vivo studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 21018-84-8
• MW: 586.54
• Purity: 99.98% (May vary between batches)
• Formula: C₂₉H₃₀O₁₃
• SMILES: OCC1OC(OC2OC=C3C(CCOC3=O)C2C=C)C(OC(=O)c2c(O)cc(O)cc2-c2cccc(O)c2)C(O)C1O
• Target: AMPK,Apoptosis
• Solubility: DMSO:2 mg/mL (3.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.7 mM)

Bioactivity

• In Vivo:
  Amarogentin, a bitter secoiridoid glycoside from S. chirayita, shows varied activity in several patho-physiological conditions, predominantly in leishmaniasis and carcinogenesis. Experimental analysis has revealed that Amarogentin downregulates the cyclooxygenase-2 (COX-2) activity and helps to curtail skin carcinogenesis in mouse models; however, there exists no account on selective inhibition of the inducible cyclooxygenase (COX) isoform by Amarogentin.marogentin inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM after 48 hours) and increases apoptosis when used at a concentration of 50 μM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMP-activated protein kinase, AMAROGENTIN, AMPK, Apoptosis, inhibit, Inhibitor

Compound Identifiers

PubChem CID

3512644