AM580

SKU: orb1220663

Description

AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )

Key Properties

• CAS Number: 102121-60-8
• MW: 351.44
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₅NO₃
• SMILES: CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
• Target: Retinoid Receptor
• Solubility: DMSO:45 mg/mL (128.04 mM)

Bioactivity

• In Vitro:
  AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium. AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells. AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD336 | NSC608001 | Ro 40-6055

Quick Database Links

Gene Symbol

Retinoid Receptor