AM580

SKU: orb1301429

Description

AM580

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 102121-60-8
• MW: 351.44
• Purity: 99.89%
• Formula: C₂₂H₂₅NO₃
• SMILES: CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
• Target: Retinoid Receptor,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.69 mM);DMSO:50 mg/mL (142.27 mM)

Bioactivity

• In Vivo:
  Modulation o the RARα/β to RARγ expression in mammary g and of normal mice, oncomice, and human mammary cell lines throug the alteration of RAR-target gene expression affected cell proliferation, survival and tumor growth. Treatment of MMTV-Myc mice wit the RARα Selective agonist Am580 led to significant Inhibition of mammary tumor growth (~90%, < .001), lung metastasis ( < .01) and extended tumor latency in 63% of mice. In these mice, RARα responsive genes such as Cyp26A1, E-cadherin, cellular retinol-binding protein 1 (CRBP1) and p27, were up-regulate.
• In Vitro:
  AM580 can inhibi the proliferation of various tumor cells,inhibiting survival signaling pathways and inducing apoptosi.
• Cell Research:
  Ishikawa cells were transfected with control siRNA or siRNA specific agains the RARα gene.Cells were treated with Vehicle control or AM580 for 18 h.Cells were stained with trypan blue and counte.
• Animal Research:
  The effects of c-Myc on RAR isotype expression were evaluated in normal mouse mammary epithelium, mammary tumor cells obtained fro the MMTV-Myc transgenic mouse model as well as human normal immortalized breast epithelial and breast cancer cell lines the in vivo effect o the RARα Selective agonist 4 [(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carboxamido]benzoic acid (Am580) was examined in the MMTV-Myc mouse model of mammary tumorigenesi.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Ro 40-6055, RetinoidReceptor, Retinoid X receptors, Retinoid Receptor, Retinoic acid receptors, RARα, RAR/RXR, CD336, CD-336, CD 336, Autophagy, AM 580, AM580, AM-580, Inhibitor, NSC608001, NSC-608001, NSC 608001, inhibit

Compound Identifiers

PubChem CID

2126