Aloesin

SKU: orb1301521

Description

Aloesin is a C-glycosylchromone isolated from Aloe species that acts as a tyrosinase inhibitor (IC50 = 0.9 mM), blocking melanin synthesis. It is widely used in dermatological research to study skin pigmentation mechanisms and as a reference compound in both in vitro enzymatic assays and in vivo models of hyperpigmentation.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 30861-27-9
• MW: 394.37
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₂₂O₉
• SMILES: CC(=O)Cc1cc(=O)c2c(C)cc(O)c([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2o1
• Target: Apoptosis,Tyrosinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.07 mM);DMSO:78 mg/mL (197.78 mM)

Bioactivity

• In Vivo:
  Aloesin prevents not only UV-B-induced immune suppression, but also could be a positive pigment-altering agent for cosmetic application. In preclinical study, aloe extract was investigated using phagocytosis and nitroblue tetrazolium chloride (NBT) reduction in adult bronchial asthma.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MCF7, MCF10A, ovarian cancer, inhibit, induce apoptosis, Aloeresin, Aloesin, antibacterium, anti-inflammatory activity, T47D, SKOV3, Tyrosinase, ultraviolet protection

Compound Identifiers

PubChem CID

160190