Alliin

SKU: orb1301512

Description

Alliin, the principal organosulfur compound from garlic, acts as a PPARγ agonist to suppress NF-κB-mediated inflammation. This mechanism underlines its research utility in models of acute lung injury (ALI), demonstrating protective effects in both in vitro and in vivo experimental settings.

Research Area

Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 556-27-4
• MW: 177.22
• Purity: 99.62% (May vary between batches)
• Formula: C₆H₁₁NO₃S
• SMILES: N[C@@H](CS(=O)CC=C)C(O)=O
• Target: PPAR,NF-κB
• Solubility: DMSO:0.44 mg/mL (2.48 mM)

Bioactivity

• In Vivo:
  LPS-induced ALI was induced in BALB/c mice by intranasal instillation of LPS. Alliin was administered intraperitoneally to mice 1 h after LPS treatment. Alliin markedly inhibited lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio induced by LPS. Alliin also inhibited TNF-α and IL-1β in the bronchoalveolar lavage fluid (BALF) induced by LPS. Furthermore, LPS-induced lung pathological injury was attenuated by treatment of alliin. LPS-induced NF-κB activation was significantly inhibited by alliin. In addition, the expression of peroxisome proliferator-activated receptor γ (PPARγ) was up-regulated by treatment of alliin. Taken together,Alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alliin, 3-(Allylsulphinyl)-L-alanine, (S)-3-(Allylsulphinyl)-L-alanine, Inhibitor, inhibit, NF-κB, NFκB, NFkB, NF-kB, PPARγ

Compound Identifiers

PubChem CID

87310