Alliin

SKU: orb1301512

Description

Alliin

Research Area

Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 556-27-4
• MW: 177.22
• Purity: 99.39%
• Formula: C₆H₁₁NO₃S
• SMILES: N[C@@H](CS(=O)CC=C)C(O)=O
• Target: NF-κB,PPAR
• Solubility: DMSO:0.44 mg/mL (2.48 mM)

Bioactivity

• In Vivo:
  LPS-induced ALI was induced in BAL-/- mice by intranasal instillation of LPS. Alliin was administered intraperitoneally to mice 1 h after LPS treatment. Alliin markedly inhibited lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio induced by LPS. Alliin also inhibited TNF-α and IL-1β in the bronchoalveolar lavage fluid (BALF) induced by LPS. furthermore , LPS-induced lung pathological injury was attenuated by treatment of alliin. LPS-induced NF-κB activation was significantly inhibited by alliin. In addition the expression of peroxisome proliferator-activated receptor γ (PPARγ) was up-regulated by treatment of alliin. Taken together Alliin protected against LPS-induced ALI by activating PPARγ, which Subsequently inhibited LPS-induced NF-κB activation and inflammatory response.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Alliin, 3-(Allylsulphinyl)-L-alanine, (S)-3-(Allylsulphinyl)-L-alanine, Inhibitor, inhibit, NF-κB, NFκB, NFkB, NF-kB, PPARγ

Compound Identifiers

PubChem CID

87310