ALK-IN-1

SKU: orb1304580

Description

ALK-IN-1 is a synthetic small molecule inhibitor of anaplastic lymphoma kinase (ALK), structurally related to Brigatinib. It is utilized in biochemical and cellular research to investigate ALK-driven signaling pathways and has been employed in both in vitro and in vivo studies to explore potential anti-tumor mechanisms.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1197958-12-5
• MW: 529.01
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₃₄ClN₆O₂P
• SMILES: N(C1=C(P(C)(C)=O)C=CC=C1)C2=NC(NC3=C(OC)C=C(C=C3)N4CCC(N(C)C)CC4)=NC=C2Cl
• Target: EGFR,ALK,IGF-1R
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:98 mg/mL (185.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.78 mM);DMSO:30 mg/mL (56.71 mM)

Bioactivity

• Target IC50:
  ALK:0.62 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGFR (C797S/del19), EGFR (del19), IGF1R, IGF-1R, AP 26113, AP26113, AP-26113, AP26113-analog, AP26113-analog, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), ALKIN1, ALK-IN-1, ALK, ALK tyrosine kinase receptor, ALK IN 1, Cluster of differentiation 246, CD246, Brigatinib, Brigatinib-analog

Compound Identifiers

PubChem CID

57390074